Acute Pancreatitis
Conditions
Keywords
Acute pancreatitis, nutrition
Brief summary
The first step in treating patients with acute pancreatitis is to provide pain relief and intravenous fluids to keep them comfortable. As the pain subsides and patient starts to feel better food and fluids by mouth are restarted. This is done to rest the pancreas which is the organ that has been inflamed. In some patients when food by mouth restarts they have pain and as a consequence they have a longer stay in hospital. It is thought that patients who have little pain and are within 24 hours of admission to hospital do well if they control their own food intake. This is in contrast to the usual treatment where the treating team advise when eating should restart.
Interventions
OTHERPatient-controlled oral refeeding
Sponsors
University of Auckland, New Zealand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of acute pancreatitis * age \> 18 years * written informed consent
Exclusion criteria
* ongoing need for opiates * \>96 hours after onset of symptoms * chronic pancreatitis * post-ERCP pancreatitis * intraoperative diagnosis * pregnancy * malignancy * received nutrition before randomisation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral food intolerance | Participants will be followed for the duration of hospital stay, an expected average of 7 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time from admission until tolerance of oral food | Participants will be followed for the duration of hospital stay, an expected average of 7 days | — |
| Total length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 7 days | — |
| Need for opiates | Participants will be followed for the duration of hospital stay, an expected average of 7 days | Need for opiates is defined when one (or more) of the following has been administered: * Codeine phosphate * Fentanyl * Morphine, Sevredol, Meslon * Oxynorm, Oxycodone * Tramadol |
| Progression of acute pancreatitis severity | Participants will be followed for the duration of hospital stay, an expected average of 7 days | To be defined according to the 2012 determinant-based classification of acute pancreatitis severity |
| Hospital readmission | 2 weeks after hospital discharge | — |
| Change in pain intensity | Baseline and 24, 48, 72h after randomisation | — |
| Number and type of interventions during hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 7 days | — |
| Time from admission until first flatus | Participants will be followed for the duration of hospital stay, an expected average of 7 days | — |
| Change in blood glucose | Baseline and 24, 48, 72h after randomisation | — |
| Change in plasma C-reactive protein | Baseline and 24, 48, 72h after randomisation | — |
| Local and systemic complications | Participants will be followed for the duration of hospital stay, an expected average of 7 days | To be defined according to the 2012 determinant-based classification of acute pancreatitis severity |
Countries
New Zealand
Outcome results
None listed