Healthy
Conditions
Keywords
no history of cardiovascular diseases
Brief summary
One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is well known that the diagnostic impact of cardiac MR investigations crucially depends on the adaption of imaging protocols to patients' state and ability to cooperate. The aim of the present study is the evaluation and optimization of various 1.5 Tesla and 3 Tesla cardiac MR investigation protocols without application of contrast agent as well as the acquisition of normal values for new cardiac MR images techniques: * normal myocardial morphology: T1-, T2- and T2\*-weighted imaging and acquisition of normal values of magnetic relaxation times (sequence- and protocol dependent), * normal cardiac function: systolic and diastolic function (sequence- and protocol dependent), * cardiac anatomy and coronary artery imaging: feasibility to evaluate length, diameter and blood flow (sequence- and protocol dependent), * normal blood flow topologies in the heart and the surrounding great vessels: 2D- and 3D blood flow imaging and evaluation techniques (sequence- and protocol dependent).
Interventions
None listed
Sponsors
Amt der Steiermärkischen Landesregierung, Abteilung 3
Medical University of Graz
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* No history of cardiac or pulmonary diseases * ability to give informed consent
Exclusion criteria
* General MR
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| magnetic relaxation times | up to 1 week | systolic and diastolic T1, T2, T2\* \[ms\], sequence- and protocol dependent |
| cardiac performance | up to 1 week | ejection fraction of cardiac chambers \[%\], sequence- and protocol dependent |
| cardiac muscle mass | up to 1 week | systolic and end-diastolic mass of cardiac chambers \[g\], sequence- and protocol dependent |
| coronary artery anatomy | up to 1 week | length and diameter \[mm\], sequence-, and protocol dependent |
| blood flow velocity | up to 1 week | maximum, minimum and average velocity \[cm/s\], sequence-, and protocol dependent |
| blood flow vorticity | up to 1 week | number of vortices of blood flow in the heart and surrounding great vessels, sequence and protocol dependent |
| blood flow timing | up to 1 week | time points of characteristic blood flow patterns in the heart and surrounding great vessels in the cardiac cycle \[ms\], sequence-, and protocol dependent |
| cardiac volumes | up to 1 week | volumes of cardiac chambers in the cardiac cycle \[ml\], sequence- and protocol dependent |
Countries
Austria
Contacts
Primary ContactUrsula Reiter, PhD
Backup ContactMichael Fuchsjäger, Prof. Dr.
Outcome results
None listed