Drug Absorption
Conditions
Keywords
metoprolol, atrial fibrillation
Brief summary
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.
Detailed description
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion. Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol. Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15
Interventions
DRUGblood concentration of metoprolol
measure blood concentration of metoprolol
Sponsors
Kuopio University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
elective CABG patient -
Exclusion criteria
contraindication to metoprolol \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| absorbtion of the metoprolol | one year | absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| atrial fibrillation | one year | is there correlation of incidence of the postopeative AF and absorbtion of the metoprolol |
Other
| Measure | Time frame | Description |
|---|---|---|
| recovery from rocedure | one year | How does gereral recovery correlate between randomized groups |
Countries
Finland
Outcome results
None listed