Long-term Cardiovascular Risk Following Successful Renal Transplantation

The Prevalence of Cardiovascular Risk Factors in Patients More Than 10 Years Following Successful Renal Transplant.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01728012

Enrollment

Registered

2012-11-16

Start date

2012-11-30

Completion date

2013-11-30

Last updated

2014-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Transplant

Keywords

Successful transplantation, Long-term observation

Brief summary

Mineral metabolism disturbances occur early during the course of chronic kidney disease and eventually affect most patients. For how long such disturbances persist after a successful renal transplantation is mainly unknown. This study will investigate the prevalence of such disturbances in patients more than 10 years following a successful renal transplantation. The patients will be recruited from an existing registry in Norway.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Registered in the Norwegian Renal Registry * Documented elevated iPTH at Tx and 10 weeks post-tx * Well functioning transplant 10 years following tx * Signed informed consent

Exclusion criteria

* Lack of ability to comply with the protocol * Refused written informed consent

Design outcomes

Primary

Measure	Time frame	Description
Fibroblast growth factor 23 (FGF23)	More than 10 years after successful renal transplantation	To evaluate the long-term effect of a successful renal transplant on this biomarker.

Secondary

Measure	Time frame	Description
Intact parathyroid hormone (iPTH)	More than 10 years after successful renal transplantation	To evaluate the long-term effect of a successful renal transplant on this biomarker.
Klotho	More than 10 years after successful renal transplantation	To evaluate the long-term effect of a successful renal transplant on this biomarker.
Neutrophil gelatinase-associated lipocalin (NGAL)	More than 10 years after successful renal transplantation	To evaluate the long-term effect of a successful renal transplant on this biomarker.

Countries

Norway

Outcome results