Type 1 Diabetes Mellitus
Conditions
Keywords
diabetes mellitus, cardiopulmonary fitness, lung function, muscular oxygenation
Brief summary
The purpose of this study is to compare the differences of 1. cardiopulmonary fitness 2. lung function 3. muscular oxygen saturation 4. quality of life between type 1 diabetes mellitus and healthy adults.
Detailed description
This study is also to investigate the relationships between cardiopulmonary fitness, lung function, muscular oxygen saturation, glycemic control, and quality of life in patients with type 1 diabetes mellitus.
Interventions
BEHAVIORALexercise testing with near-infrared spectroscopy
subjects will sit on the ergometer, resting heart rate and BP will be measured for at least 2 minutes. Before testing, each participant will be informed to perform cycling with 0 watt for 2 minutes. Then, exercise testing will be started at 30 watt, and increase 15 watt in male and 10 watt in female every minute until the termination criteria achieved.
BEHAVIORALlung function testing
spirometry testing: Each participant will then place mouthpiece in mouth and close lips around the mouthpiece. Participants will inhale completely and rapidly and then exhale maximally until no more air could be expelled while maintaining an upright position. Values of FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) will be calculated immediately after the exhalation. single-breath carbon monoxide diffusing capacity: Participants will sit on a firm and nose clips will then be attached and mouthpiece be placed in mouth. After participants perform several stable breathes, testing starts with a complete exhalation. Each participant will be instructed to inhale rapidly and completely and then hold for 10 seconds.
BEHAVIORALquality of life
assessing quality of life using short-forum 36 (questionnaire)
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosis of type 1 diabetes mellitus ≥2 years (diabetic group) * age-, gender-, and BMI-matched healthy subjects (control group)
Exclusion criteria
* cardiac or respiratory disease * pregnancy * hospitalization due to any medical condition in recent 6 months * any other condition affecting exercise performance or lung function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| exercise testing with near-infrared spectroscopy | at baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| lung function | at baseline | flow volume loop, lung diffusing capacity |
| quality of life | at baseline | short-forum 36 |
Countries
Taiwan
Outcome results
None listed