NEFA (Non Esterified Fatty Acid) , Adipose Factors Behind Insulin Sensitivity

The Role of Adipose Tissue in Atherogenic Conditions in Man - Mechanisms and Interventions

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01727245

Enrollment

500

Registered

2012-11-15

Start date

2011-11-30

Completion date

2019-12-31

Last updated

2020-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-obese Controls, Obesity

Brief summary

We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).

Interventions

OTHERObese

gastric bypass

OTHERControl group

Cholecystectomy and anti-reflux surgery

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

obese: * Bariatric surgery with laparoscopic gastric by-pass

Exclusion criteria

obese: * diabetes mellitus typ 2 with insulin treatment and/or glitazones * oral or parenteral steroid treatment * complicated psychiatric disease * Warfarin use Inclusion Criteria non-obese controls: * BMI under 30

Design outcomes

Primary

Measure	Time frame	Description
Insulin sensitivity, adipose tissue function and gene function	two years after surgery	Performed with hyperinsulinemic euglycemic clamp before and two years after surgery. Subcutaneous and visceral fat biopsy at the time of surgery.

Secondary

Measure	Time frame	Description
Body composition	two years after surgery	DEXA (Dual-Energy X-ray absorptiometry), before and two years after surgery
Vascular function	two years after surgery	Non invasive ultrasound of vascular stiffness, before and two years after surgery

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026