Postoperative Pain Relief
Conditions
Keywords
transdermal fentanyl patch, postoperative pain,
Brief summary
Abdominal surgery causes severe postoperative pain. Multi-modal pain therapy is usually applied but there is no perfect choice. It depends on physician's skill and situation. The best regimen is patient-controlled analgesia, but it requires an expensive equipment. Transdermal fentanyl patch, usually used in chronic pain relief, can steadily release fentanyl into blood stream for 72 hours, but it has slow onset of 12 hours. Hypothesis: If Transdermal fentanyl patch is applied 10-12 hours before surgery, it may provide good analgesia for 72 hours.
Interventions
DRUGtransdermal fentanyl patch (50 mcg/hour)
DRUGPlacebo
Sponsors
Khon Kaen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* age =\>18 years * scheduled for abdominal surgery
Exclusion criteria
* ASA class \> 3 * Known allergy to fentanyl or morphine * History of substance or alcohol abuse, and tolerance or dependence on opioids * Combined epidural block * Can't use PCA, abnormal renal / liver function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| morphine consumption | 24 hours | Compare the cumulative morphine consumption during 24 hours postoperative of both study and control groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| morphine consumption | 48 and 72 hours | Compare the cumulative morphine consumption during 48 and 72 hours postoperative of both study and control groups. |
Other
| Measure | Time frame | Description |
|---|---|---|
| side effects | 72 hours | Compare the side effects, i.e.nausea, vomiting, itching, respiratory depression during 72 hours postoperative of both study and control groups. |
Countries
Thailand
Outcome results
None listed