Adverse Effect of Oxytocic Drugs, Inappropriate Dose of Drug Administered, Uterine Hemorrhage
Conditions
Keywords
Oxytocin, Uterine tone, Mulago Hospital, Dose, Side effects
Brief summary
The purpose of the study was to determine whether 2.5 international units of oxytocin gives adequate uterine tone and is safe as compared to 10 international units of oxytocin following caesarean section delivery at Mulago hospital.
Interventions
DRUG2.5 units Oxytocin
Administration of 2.5 units of oxytocin after clamping of umbilical cord
DRUG10 units Oxytocin
Administration of 10 units of oxytocin after clamping of umbilical cord
Sponsors
Faculty of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA I (Healthy patient with no systemic disease) or II ( mild to moderate systemic disease) * Age between 18 to 40 years * Singleton pregnancies
Exclusion criteria
* • Allergy to oxytocin * Ruptured uterus * Significant obstetric disease (including Pregnancy induced Hypertension, Eclampsia,) * Known risk factors for postpartum haemorrhage or uterine atony * Inherited or acquired coagulation disorder * History of post partum haemorrhage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Uterine tone adequacy | 2 minutes | The primary outcome was the assessment of either adequate or inadequate Uterine tone at various times after administration of initial oxytocin dose |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative blood loss | 24 hours | Blood loss was estimated by measuring the amount in the suction bottles and weighing of the mops. The patients were followed up for any occurrence of postpartum haemorrhage for the next 24 hours after surgery. |
Countries
Uganda
Outcome results
None listed