Perioperative Pregabalin and Continuous Wound Infusion for Pain Control Following Thoracotomy

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01726205

Enrollment

Registered

2012-11-14

Start date

2008-10-31

Completion date

2012-05-31

Last updated

2012-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-thoracotomy Pain

Brief summary

The purpose of this study is to assess the efficacy of pregabalin or pregabalin and continuous wound infusion versus placebo for analgesia following thoracotomy

Interventions

DRUGPregabalin and normal saline infusion, PRG

DRUGPregabalin and ropivacaine 02% infusion

DRUGPlacebo drug, normal saline infusion

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients scheduled for a thoracotomy,

Exclusion criteria

* age \>70 years * BMI \> 30 * preoperative Hb \< 10 mg/dL * preexistent chronic pain * neurologic disease * chronic assumption of alcohol * treatment with analgesics, anxiolytics, sedatives, antidepressants, or calcium channel inhibitors

Design outcomes

Primary

Measure	Time frame
Pain control	5 days postoperatively

Secondary

Measure	Time frame
morphine consumption	3 days postoperatively

Other

Measure	Time frame
side effects, pain at 1 and 3 months, incidence of neuropathic pain	3 months

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026