Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01725607

Enrollment

219

Registered

2012-11-14

Start date

2013-01-31

Completion date

2014-03-31

Last updated

2015-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anesthesia, Thoracic Epidural Anesthesia

Keywords

dexmedetomidine, thoracic epidural anesthesia

Brief summary

We designed a study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Detailed description

We designed a prospective, single-blinded, randomized, and controlled study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.

Interventions

DRUGgeneral anesthesia combined with dexmedetomidine infusion

general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D)

PROCEDUREgeneral anesthesia combined with TEA

general anesthesia combined with TEA (Group E)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* lung surgery * one-lung ventilation.

Exclusion criteria

* body mass index exceeding 30 kg/m2, * autonomic dysfunction, * cardiovascular disease, * neurological or psychiatric diseases

Design outcomes

Primary

Measure	Time frame	Description
inflammatory cytokine secretion and postoperative sleep quality	immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6)	Primary outcomes were inflammatory cytokine secretion and postoperative sleep quality, which was measured with the BIS data on first and second postoperative nights.

Secondary

Measure	Time frame	Description
amine secretion during the surgical period and hemodynamic stability	immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6)	amine (epinephrine and norepinephrine) secretion during the surgical period and hemodynamic stability

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026