Female Sexual Dysfunction
Conditions
Keywords
female sexual function, postmenopause, testosterone
Brief summary
Additional testosterone undecanoate can improve female sexual function in postmenopausal women which one aspects of quality of life. The dose adjustment can reduce incidence of adverse effects and low cost of treatment with effective outcome.
Detailed description
Research Question: Does oral testosterone undecanoate improve sexual problem in postmenopausal women? Type Research:Clinical research Study design: Randomized double-blinded placebo controlled trial
Interventions
DRUGTestosterone undecanoate
testosterone undecanoate 40 mg orally twice a week
DRUGplacebo
placebo orally twice a week with progynova 1 mg oral daily
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* postmenopausal women with age between 40-60 years * Women complain about her sexual problem and her score of Female Sexual Function Index ≤ 26.5
Exclusion criteria
* women with previous use of hormonal replacement or anti-psychiatric drugs within 3 months * women with history of or present premalignancies/malignancies * women present with liver disease or abnormal liver enzyme * women with active cardiovascular, cerebrovascular or thromboembolic disorders * women with Present psychiatric disease * Partner have sexual dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| female sexual function index score | 8 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adverse effects of the drug | 8 week | 1. weight gain 2. acne 3. hirsutism. 4. vaginal bleeding |
Countries
Thailand
Outcome results
None listed