Acute Respiratory Distress Syndrome After Cardiac Surgery Under Cardiopulmonary Bypass
Conditions
Brief summary
Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line. Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient man or woman \> 18 y.o. * Patient has signed informed consent prior to the study * Patient affiliated to a social security administration * Patient operated on for cardiac surgery at the University Hospital of Strasbourg. * Patient at high risk for postoperative respiratory failure defined by a SLIP score (Kor et al.) ≥ 22 Kor: * High-risk cardiac intervention under cardiopulmonary bypass (19 pts) * COPD (10 pts) * Diabetes (6 pts) * gastroesophageal reflux (7 pts) * Alcohol abuse (11 pts) * Scheduled use of a pulmonary artery catheter and a left atrial catheter
Exclusion criteria
* Inability to obtain informed consent from the patient and / or unable to give informed patient information (difficulty understanding ...) * Urgent surgery (\<24h) * Acute heart failure * Patient ventilated preoperatively * Allergy to Latex * Persons deprived of liberty or under judicial protection * Patient placed under guardianship * Pregnancy * Breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance | during the surgery | Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass. |
Countries
France
Contacts
Primary ContactJulien POTTECHER, MD
Outcome results
None listed