Vitamin D Intervention in Infants

Conditions

Vitamin D Status

Keywords

Vitamin D, Infectious diseases, cognitive development, Bone mineral density, Immunoregulation, Allergy, Growth

Brief summary

The study is a randomized, controlled, double blinded study evaluating the effect of recommended (400 IU) and 1 200 IU daily vitamin D substitution, given from 2 weeks to 2 years of age, on growth, bone development, neurologic and cognitive development, frequence of infectious diseases, allergic symptoms, and development of immunoregulation assessed at 2 years of age.

Seppälä V, Sandboge S, Holmlund-Suila E, Hauta-Alus H, Lintula S, Kajantie E, Mäkitie O, Andersson S, Räikkönen K, Heinonen K.

2025-10-10

10.1007/s00787-025-02891-7

Variation in the fibroblast growth factor 23 (FGF23) gene associates with serum FGF23 and bone strength in infants

Maria Enlund-Cerullo, Elisa Holmlund‐Suila, Saara Valkama, Helena Hauta‐alus, Jenni Rosendahl et al. (8 authors)

Frontiers in Genetics2023-05-223 citations

10.3389/fgene.2023.1192368

Effect of Vitamin D<sub>3</sub> Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years

Samuel Sandboge, Katri Räikkönen, Marius Lahti‐Pulkkinen, Helena Hauta‐alus, Elisa Holmlund‐Suila et al. (10 authors)

JAMA Network Open2023-05-1911 citations

10.1001/jamanetworkopen.2023.14319

Iron status in early childhood is modified by diet, sex and growth: Secondary analysis of a randomized controlled vitamin D trial

Elisa Holmlund‐Suila, Helena Hauta‐alus, Maria Enlund-Cerullo, Jenni Rosendahl, Saara Valkama et al. (7 authors)

Clinical Nutrition2021-12-1311 citations

10.1016/j.clnu.2021.12.013

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation on Neurodevelopment of Healthy Term Infants

Soile Tuovinen, Katri Räikkönen, Elisa Holmlund‐Suila, Helena Hauta‐alus, Otto Helve et al. (13 authors)

JAMA Network Open2021-09-0818 citations

10.1001/jamanetworkopen.2021.24493

Effect of Higher vs Standard Dosage of Vitamin D<sub>3</sub>Supplementation on Bone Strength and Infection in Healthy Infants

Jenni Rosendahl, Saara Valkama, Elisa Holmlund‐Suila, Maria Enlund-Cerullo, Helena Hauta‐alus et al. (12 authors)

JAMA Pediatrics2018-05-2973 citations

10.1001/jamapediatrics.2018.0602

Maternal vitamin D status, gestational diabetes and infant birth size.

Hauta-Alus HH, Viljakainen HT, Holmlund-Suila EM, Enlund-Cerullo M, Rosendahl J, Valkama SM, Helve OM, Hytinantti TK, Mäkitie OM, Andersson S.

2017-12-1525 citations

10.1186/s12884-017-1600-5

Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) - study design and methods of a randomised controlled double-blinded intervention study.

Helve O, Viljakainen H, Holmlund-Suila E, Rosendahl J, Hauta-Alus H, Enlund-Cerullo M, Valkama S, Heinonen K, Räikkönen K, Hytinantti T, Mäkitie O, Andersson S.

2017-03-2928 citations

10.1186/s12887-017-0845-5

Interventions

DIETARY_SUPPLEMENTVitamin D at 30 ug/day

DIETARY_SUPPLEMENTVitamin D at 10 ug/day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

No minimum to 5 Days

Healthy volunteers

Yes

Inclusion criteria

* Infants born at term (37-42 wks, weight appropriate for gestational age) are included in the study

Exclusion criteria

* Non Caucasian mother * Any continuous regular medication of mother * Treatment at neonatal intensive care unit * Antibiotic treatment of the infant * Congenital malformations of the newborn * Treatment with ventilation support (continuous nasal positive airway pressure) for over 24 hours * Glucose infusion of the newborn * Neurological symptoms of the newborn * Phototherapy for jaundice of the newborn * Need for nasogastric feeding of the newborn

Design outcomes

Primary

Measure	Time frame	Description
Growth	2 years of age	Measurement of growth at 2 years of age
Neurologic and cognitive development	At 2 years of age	By means of questionnaires and, on a randomly selected group of study subjects, cognitive function testing to assess neurologic and cognitive development
Frequency of allergic symptoms and infection	At 2 years of age	Assessment of the frequency of allergic symptoms and infections by means of questionnaires, hospital discharge records and prescription data.
Development of immunoregulation	At 2 years of age	Assessment of the tolerogenic properties of T-cells and dendritic cell function from blood sample in a subgroup of 100 study subjects.
Bone mineral density	2 years of age	Bone mineral density is measured by dual energy x-ray absorptiometry and peripheral quantitative computerized tomography

Countries

Finland

Outcome results

None listed