Intracranial Aneurysms
Conditions
Keywords
dexmedetomidine, endovascular coil embolization
Brief summary
The investigators designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine on the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.
Interventions
DRUGsevoflurane and 0.5 μg/kg dexmedetomidine
After induction of general anesthesia, Group DEX1 received a single dexmedetomidine dose of 0.5 μg/kg over 10 minutes.
DRUGsevoflurane and 1 μg/kg dexmedetomidine
After induction of general anesthesia, Group DEX2 received a single dexmedetomidine dose of 1 μg/kg over 10 minutes.
Sponsors
China Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
18-65 years old ASA I or ASA II patients undergoing ECE treatment for intracranial aneurysms were included.
Exclusion criteria
Patients were excluded based on the following parameters: older than 65 yrs, a history of mental illness, recent use of sedatives or analgesics and with sensation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Observing the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization. | At the end of the operation and 24 hours later | The time from termination of the general anesthetic to the time that the patient's eyes opened. Anesthesiologists collected information on emergence agitation, postoperative nausea and vomiting for 24 hours after the surgery. |
Countries
China
Outcome results
None listed