Atrial Fibrillation
Conditions
Keywords
Atrial Fibrillation, Exercise Training, Endothelial Function, Autonomic Nerve Modulation, Exercise Capacity, Quality of Life
Brief summary
Atrial fibrillation (AF) is a common arrhythmia. The proposed patholophysiological mechanisms of AF include abnormal electrical conduction in atrium and sympathovagal imbalance with increased vagal tone. Patients with AF have poor exercise capacity that may contribute to decreased atrial effective refractory period, and decreased cardiac output and heart rate reserve, and may result in poor quality of life. Poor endothelial function had been noted in patients with AF, associated with increased risks of cerebrovascular and cardiovascular disease. Exercise training has been noted to improve exercise capacity and quality of life in patients with AF only in some studies. Endothelial function can be improved by exercise training in patients with cardiovascular disease, but no report in patients with AF. Evidence of exercise training is still needed in patients with AF. The purpose of this study is to investigate the effect of exercise training on 1. endothelial function 2. heart rate variability 3. exercise capacity 4. quality of life.
Detailed description
A randomized controlled study was implemented to examine :(1) the effect of interval aerobic exercise training combined with resistance training on endothelial function, heart rate variability (HRV), exercise capacity, and quality of life (QoL); (2) the influential factors related to exercise capacity, and the relationship between exercise capacity and quality of life in patients with permanent atrial fibrillation (AF).
Interventions
OTHERExercise training
Exercise group will undergo progressively aerobic exercise training with 40-85% maximal oxygen consumption for 40 minutes, 3 sessions per week for 12 weeks.
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 76 Years
Healthy volunteers
Yes
Inclusion criteria
* Permanent atrial fibrillation≥ 1 year aged 40-76 years * Recurrence AF after ablation * Under antiarrhythmia medication control
Exclusion criteria
* CAD or myocardial infrarction history * NYHA≥ III-IV, or LVEF≤45% * Mitral or aortic valve regurgitation ≥ Gr. II * Mitral valve or aortic valve stenosis * Pacemaker * Cardioversion by ablation * Pulmonary artery hypertension * Any surgery in previous 3 months * Any neurological disorders * Cancer * Severe musculoskeletal disorder * Hyperthyroidism * Premenopausal women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of exercise capacity (after intervention) | At baseline and 12 weeks after intervention | To measure maximal oxygen consumption, maximal oxygen pulse, maximal heart rate and blood pressure, cumulated and peak workload by cycle ergometer with Vmax 229 system |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of heart rate variability (after intervention) | At baseline and 12 weeks after intervention | To record ECG by lead V1 with KENZ 170 on supine position for 1 hour |
| Change values of head up tilt test (after intervention) | At baseline and 12 weeks after intervention | Subjects were tilted up 60 degree on tilting table for 15 minutes to record the change of blood pressure and heart rate, and heart rate variability. |
| Change of endothelial function (after intervention) | At baseline and 12 weeks after intervention | To measure dependent-endothelial moulation by flow-mediated dilatation with Sonosite 180 portable ultrasound. |
| Change of quality of life (after intervention) | At baseline and 12 weeks after intervention | To measure quality of life by Short-form 36 and symptom checklist |
Countries
Taiwan
Outcome results
None listed