Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01721811

Enrollment

120

Registered

2012-11-06

Start date

2012-10-31

Completion date

Unknown

Last updated

2015-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Individuals, Patients With Diabetes.

Brief summary

The aim of the study is to investigate how the retina adapts to different metabolic challenges, e.g. chronic systemic hypoxia, hyperglycemia, special training conditions or diets as well as transient changes in the content of oxygen and glucose in the blood.

Interventions

OTHERHyperoxia

OTHERGlucose

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy individuals Inclusion Criteria: * Healthy volunteers. * No known systemic or ocular disease.

Exclusion criteria

* Any systemic or ocular disease. Patients with diabetes Inclusion criteria: * Diabetes mellitus * No intraocular disease other than conditions attributable to diabetes.

Design outcomes

Primary

Measure	Time frame	Description
Retinal vessel diameters during hyperoxia	Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia	Measurement of retinal vessel diameters before, during and after hyperoxic stimulation.
Retinal perfusion velocities during hyperoxia	Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia	Measurement of retinal perfusion velocities before, during and after hyperoxic stimulation.
Retinal oximetry during hyperoxia	Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia	Measurement of retinal oximetry status before, during and after hyperoxic stimulation.
Retinal vessel diameters during hyperglycemia	Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load	Measurement of retinal vessel diameters before, during and after hyperglycemic stimulation.
Retinal perfusion during hyperglycemia	Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load	Measurement of retinal perfusion velocities before, during and after hyperglycemic stimulation.
Retinal oximetry during hyperglycemia	Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load	Measurement of retinal oximetry status before, during and after hyperglycemic stimulation.

Countries

Denmark

Contacts

Primary ContactOliver Klefter, MD

+45 38 63 48 18

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026