Satiety Effects on the Neural Valuation of Food

Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01721187

Enrollment

Registered

2012-11-05

Start date

2012-10-31

Completion date

2014-07-31

Last updated

2015-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fasting, Fed

Keywords

fMRI, Satiety, Willingness to Pay, Incentive Delay, Dietary Disinhibition

Brief summary

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Chinese ethnicity * 21 to 45 years old * English as first language * Right-handed * Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses) * Weigh less than 100kg with an abdominal circumference of less than 120cm * Non-smoker, or only smoke occasionally (less than 5 sticks a week) * Consume less than 2 units (200 mg) of caffeine a day * Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit) * Habitually sleep before 1am and wake before 9am

Exclusion criteria

* On a restrictive diet (e.g., vegetarian/vegan diet) * History of food allergies * History of psychiatric or neurological disorders * History of chronic medical illness * Metal implants in or on the body (e.g. braces, dental retainers, pacemakers) * Shift worker * Claustrophobic * High astigmatism (high = \>2.00 diopters) * Colour-blind

Design outcomes

Primary

Measure	Time frame	Description
fMRI - Willingness to Pay task (BDM auction)	Fed and fasted visits (Wks 1 & 2)	A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.
fMRI - Monetary and Food Incentive Delay task	Fed and fasted visits (Wks 1 & 2)	A measurement of neural response to anticipating and receiving money and food rewards.

Countries

Singapore

Outcome results