Traumatic Brain Injury
Conditions
Keywords
TBI, Traumatic Brain Injury, Children, Prognosis, Neurocognition
Brief summary
Traumatic Brain Injury (TBI) is the world leading cause of acquired brain injury. Literature suggests a pivotal role for attentional functioning in neurocognitive and behavioural consequences of paediatric TBI. Limitations of traditional neuropsychological measures of attentional functioning have interfered with identification of the effect of paediatric TBI on attentional networks so far. Moreover, the associations between attentional networks, learning abilities, academic performance and behavioural and emotional problems following paediatric TBI are yet to be explored.
Detailed description
Background: Traumatic brain injury (TBI) is the world leading cause of disability in children (Winslade, 1998), causing deficits in motor function, neurocognition and adaptive behaviour (Anderson, 2001). Literature shows that age at injury is inversely related to the magnitude of deficits following TBI, highlighting the vulnerability of children for the effects of TBI. The neurocognitive consequences of paediatric TBI have primarily been characterized by impairments in speed of information processing, attentional functioning and learning (Babikian & Asarnow, 2009; Catroppa & Anderson, 2009), interfering with typical neurocognitive development. We aim at elucidating the effects of TBI on neurocognitive function and investigate the relations between neurocognitive deficits, academic achievement and emotional and behavioural function, in order to improve our understanding of the post-injury functioning of children that have suffered TBI. Methods: Patients with TBI will be compared to a control group consisting of orthopedically injured patients. Orthopaedic control (OC) groups offer a better comparison to TBI patients than typically developing children by controlling for TBI risk factors related to neurocognition (e.g. Attention Deficit Hyperactivity Disorder, socioeconomic status), hospitalisation and the type of injuries other than brain injuries. Measures: Child's Orientation and Amnesia Test, Attention Network Test, Probabilistic Learning Test, Child Behaviour Checklist, Strengths & Difficulties Questionnaire, Experimental Neurocognitive Test developed at the VU University and Pupil Monitoring System.
Interventions
None listed
Sponsors
Amsterdam UMC, location VUmc
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Marsh Königs
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
TBI patients will be included if they * have parental written informed consent * provide written informed consent if aged over 11 years * are Dutch speaking * have a clinical diagnosis of TBI (closed head injury) * have a time post-injury that is longer than 1 month * are aged between 6-12 years. Trauma control patients will be included if they: * have parental written informed consent * provide written consent if aged over 11 years * are Dutch speaking * have suffered an orthopaedic injury * have no history of TBI * and are aged between 6-12 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The white-matter integrity of children with TBI will be compared to children with traumatic control injuries | on average 1-year post-TBI | FA/ADC values will be reported for selected region's of interest in children with TBI and children with traumatic control injuries. |
| Performance on tests of attention will be compared between children with TBI and children with traumatic control injuries | on average 1-year post-TBI | Mean reaction time and accuracy will be reported for children with TBI and children with traumatic control injuries |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Parental reports of behavioural regulation will be compared between children with TBI and children with traumatic control injuries | on average 1-year post-TBI | Problem scores on several types of behavioural problems will be reported for children with TBI and children with traumatic control injuries |
| Academic achievement will be compared between children with TBI and children with traumatic control injuries | on average 1-year post-TBI | Scores on standardised tests of academic achievement will be reported for children with TBI and children with traumatic control injuries |
| Performance on test of reinforced learning will be compared between children with TBI and children with traumatic control injuries | on average 1-year post-TBI | Reaction time and accuracy on computerised tests of reinforced learning will be reported for children with TBI and children with traumatic control injuries |
Countries
Netherlands
Outcome results
None listed