Chronic Migraine, Healthy Controls, Migraine With and Without Aura
Conditions
Keywords
migraine, episodic migraine, chronic migraine, obesity, non-obese
Brief summary
This research is being done to look at the association between migraine and obesity.
Detailed description
Research into the role of inflammatory markers and other obesity related proteins and chemicals may help us understand migraine and lead to new treatment.
Interventions
None listed
Sponsors
Johns Hopkins University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Premenopausal women (18-55 years) * Normal weight (BMI = 18.5 - 24.9) or obese (BMI ≥ 30) * Diagnosis of episodic or chronic migraine or pain free control
Exclusion criteria
* Evidence of pain disorder other than migraine (e.g. irritable bowel syndrome) * Chronic conditions known to alter risk or pattern of migraine (e.g. hypothyroidism) * Illnesses that may affect adipokine levels (e.g. diabetes) * Clinically relevant abnormal glucose/cholesterol levels * Pregnant women * Potential participants who are unable to undergo MRI based on standard screening questionnaire (those with brain aneurysm or surgical clips, certain types of artificial heart valves, heart defibrillator or pacemaker, cochlear implants, eye implants, blood vessel coil, recently placed artificial joints, certain types of vascular stents, history of bullets, pellets, BBs, history of any implanted metal or device or who have worked with sheet metal in the past)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| association between migraine and obesity - evaluate serum adipokine levels | 5 years | The first aim of the proposed research is to evaluate serum adipokine levels in a clinical cohort of obese and non-obese episodic and chronic migraineurs and examine their utility as markers of the presence or absence of migraine and their relationship to headache frequency. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| association between migraine and obesity -evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT) | five years | The second aim of the proposed research is to evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT),in the same clinical cohort of migraineurs to determine if regional adipose tissue differences exist between: (1) episodic migraineurs, (2) chronic migraineurs and (3) controls, thus contributing to the migraine-obesity relationship. |
Countries
United States
Outcome results
None listed