Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease

Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01720758

Acronym

B-RAF V600E

Enrollment

Registered

2012-11-02

Start date

2012-11-30

Completion date

2013-04-30

Last updated

2017-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hairy Cell Leukemia, Splenic Marginal Zone Lymphoma

Brief summary

The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. The finding of this specific mutation will help to verify or exclude the diagnosis of Hairy Cell Leukemia and determine whether patients are in remission.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients over the age of 18 years -

Exclusion criteria

Patients less than 18 years in age or mentally defectives. \-

Design outcomes

Primary

Measure	Time frame
detection of the B-RAF V600E mutation	2 weeks

Outcome results