Childhood Obesity
Conditions
Keywords
Obesity, Dietary fat, Energy expenditure, Food intake
Brief summary
The purpose of this study is to test the effects of a cooking oil blend of dietary fats rich in medium chain triglycerides on energy expenditure and food intake in overweight and obese children.
Interventions
DIETARY_SUPPLEMENTMelt (test oil)
DIETARY_SUPPLEMENTCorn oil (control)
Sponsors
Prosperity Organic Foods
USDA Beltsville Human Nutrition Research Center
St. Luke's-Roosevelt Hospital Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
15 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* age 15-18 * body mass index 85% percentile or higher for age/sex * weight stable
Exclusion criteria
* ±5 lbs weight change in the the 3 months prior * use of medications * dietary allergies * metabolic disorder * eating disorder * behavioral or psychological disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thermic effect of food | 6 h | Measurement of thermic effect of food over 6 hours after a meal rich in test oil and control oil. The thermic effect of food is the difference between post-prandial energy expenditure and basal energy expenditure. We will assess the difference in thermic effect of food over a 6-hour period between the test oil and the control oil. |
| Respiratory quotient/fat oxidation | 6 h | Measurement of substrate oxidation by indirect calorimetry over 6 hours after consumption of the test oil and control oil. We will specifically calculate carbohydrate and fat oxidation rates over the 6-hour period post-prandially and compare rates of oxidation of these two substrates between the test oil and the control oil. |
| Food intake | single meal | Measurement of food intake at a single meal served 1 hour after a pre-load containing 8-10 g of the test oil and the control oil |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Leptin | 6 hours | Measurement of leptin over 6 hours after consumption of the test oil and control oil |
| Ghrelin | 6 hours | Measurement of ghrelin over 6 hours after consumption of the test oil and control oil |
| Glucose | 6 h | Measurement of glucose over 6 hours after consumption of the test oil and control oil |
| Glucagon like peptide 1 | 6 hours | Measurement of glucagon like peptide 1 over 6 hours after consumption of the test oil and control oil |
| Peptide YY | 6 hours | Measurement of peptide YY over 6 hours after consumption of the test oil and control oil |
| Feelings of appetite and satiety | 6 h | Measurement of feelings of appetite and satiety by visual analog scales over 6 hours after consumption of the test oil and control oil |
| Insulin | 6 hours | Measurement of insulin over 6 hours after consumption of the test oil and control oil |
Countries
United States
Outcome results
None listed