General Surgery With Endotracheal Intubation
Conditions
Brief summary
To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients
Detailed description
The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients.
Interventions
DRUGremifentanil
The effect site concentration of remifentanil
Sponsors
Severance Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 65 years ASA class I-II who received surgery with endotracheal intubation
Exclusion criteria
* emergency surgery * electrocardiography abnormality * hypertension * diabetes mellitus * end stage renal disease * moderate to severe cardiac disease * moderate to severe liver dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect site concentration for preventing QTc interval prolongation | 2 min |
Countries
South Korea
Outcome results
None listed