Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01720472

Acronym

PPS

Enrollment

1000

Registered

2012-11-02

Start date

2012-05-01

Completion date

2018-08-28

Last updated

2026-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Cognitive Functioning, Fitness, Physical Functioning

Keywords

Aging, Healthy Aging, Physical Performance, Physical Functioning, Cognitive Functioning, Fitness, Physical Activity

Brief summary

The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Detailed description

The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

Interventions

GENETICBiomarker studies

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year. * Age 30 or older

Exclusion criteria

* Female that is currently pregnant * Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months * Participant that requires consent by a legally authorized representative * Participant that cannot walk 30ft without human assistance

Design outcomes

Primary

Measure	Time frame	Description
Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository	Upto 2 years or 24 months	Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORVirginia Byers Kraus, MD, Ph.D.

Duke University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 8, 2026