Keloid Scars
Conditions
Brief summary
Keloid scarring is a severe cosmetic and painful disease of the skin. The gold standard treatment is yet to be clarified. This randomized clinical pilot study will compare the effects of two local treatments for preventing keloid recurrence after surgical removal; steroid and verapamil. Study hypothesis: Intralesional therapy with the calcium antagonist verapamil has equal treatment efficacy as steroid injection.
Interventions
DRUGVerapamil
DRUGKenalog 10
Sponsors
The University of Western Australia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient undergoing surgical removal of keloid * Patient 18 years old or greater * Length of excisional scar after surgical removal of keloid between 2 and 10 cm
Exclusion criteria
* Keloid in face or hands * Pregnancy or lactation * Dementia * Any heart or pulmonary condition * Systemic treatment with beta-blockers, ACE-inhibitors or calcium antagonists * Systemic corticosteroidal therapy * Intralesional steroid treatment within 2 months of surgery to remove keloid * Flap surgery * Lesions to face, hands and other cosmetically sensitive areas
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Keloid recurrence | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Vancouver Scar Scale Score | 1 year |
Countries
Australia
Outcome results
None listed