Functional MRI of Stress in Obesity

Functional Magnetic Resonance Imaging of Stress in Obesity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01719484

Enrollment

Registered

2012-11-01

Start date

2008-05-31

Completion date

2014-03-31

Last updated

2022-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

To examine the influence of obesity on brain activation during food cue, stress, and neutral relaxing conditions

Detailed description

Subjects will participate in an fMRI session to examine changes in frontal and limbic brain regions with food cues, stress and neutral/relaxing imagery

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. Between ages 18-50 years old. 2. Able to read and write. 3. negative urine toxicology screens during intake appointments indicating no history of current or past dependence on alcohol or illicit drug use. 4. WOMEN: have a regular menstrual cycle. 5. BMI: 30 \< BMI \< 35 for obese subjects (upper limit of 35 selected given our experience with heavier individuals fitting comfortably in the fMRI scanner) and 18.5 \< BMI \<25 for normal weight subjects (Institute, 2006)

Exclusion criteria

1. any major neurological illness or injury and any current or prior clinically significant mental health (including PTSD) or substance use disorder (with exception of nicotine dependence) as determined by SCID interview; 2. Regular use of any psychoactive drugs including anxiolytics and antidepressants. 3. Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, liver, thyroid pathology; subjects on medications for any medical condition will be excluded. 4. Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded including subjects who work as welders. 5. Women on oral contraceptives, peri- and post-menopausal women, and pregnant or lactating women (as alterations in stress response are associated with these states).

Design outcomes

Primary

Measure	Time frame
No outcome measures for this study, this is an imaging study only	Upon study completion

Countries

United States

Outcome results