Genetic Basis of Mitral Valve Prolapse

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01719211

Acronym

MVP

Enrollment

1500

Registered

2012-11-01

Start date

1999-01-31

Completion date

2025-12-31

Last updated

2023-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mitral Valve Prolapse

Keywords

MVP, mitral valve

Brief summary

The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Detailed description

This is a genome-wide association study.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Mitral valve prolapse

Exclusion criteria

* Other mitral valve diseases

Design outcomes

Primary

Measure	Time frame	Description
Discovery of the genetic basis of Mitral Valve Prolapse	5 years	Genome-wide association

Countries

United States

Contacts

Primary ContactSusan Slaugenhaupt, PhD

slaugenhaupt@chgr.mgh.harvard.edu6176433217

Backup ContactRobert a levine, MD

rlevine@partners.org6177241995

Outcome results