Allergic Rhinitis
Conditions
Keywords
allergy, birch
Brief summary
Assessment of skin reactivity by skin prick tests to synthetic peptides derived from the major birch allergen bet v 1, in subjects allergic to birch pollen.
Detailed description
The study tested - all by skin tests - in the same group of 20 trial subjects, one positive control (histamine solution), one negative control (placebo saline) and five experimental peptides called T1, T2, T3, T4 and T5. Results of the skin prick tests were scored as negative (no reaction) or positive (wheal diameter \> 4 mm with erythema)
Interventions
DRUGplacebo
saline solution
DRUGHistamine
positive control
DRUGAllerT1
synthetic peptide T1
DRUGAllerT2
synthetic peptide T2
DRUGAllerT3
synthetic peptide T3
DRUGAllerT4
synthetic peptide T4
DRUGAllerT5
synthetic peptide T5
DRUGmix of AllerT1-T2-T3
mix of peptides T1, T2 and T3
DRUGmix of AllerT4-T5
mix T4-T5
Sponsors
Anergis
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* history of allergy symptoms during previous birch pollen season * positive skin prick test to birch pollen extract
Exclusion criteria
* pregnancy * uncontrolled asthma * other significant clinical conditions or immune disorders * subjects taking antihistamines or drugs with antihistamine activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin prick test reactivity | 15 minutes |
Countries
Switzerland
Outcome results
None listed