Periodontal Disease
Conditions
Keywords
periodontal disease, bleeding on probing, periodontal pockets, disabled
Brief summary
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush. These patients have considerable periodontal disease. There is a concern that these pathogens may have a detrimental effect on wound healing in other areas of the body. Hypothesis: Patients attending the dental department at TRI that are treated with the antibiotic-antifungal rinse containing metronidazole and nystatin will show substantial decrease in periodontal disease as measured by bleeding points and pocket depth when compared to the group that continues to use their regular oral hygiene methods (control group).
Interventions
DRUGmetronidazole-nystatin oral rinse
Sponsors
Oravital Inc
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Participants must be between the ages of 18 to 65 years Participants must have at least 6 teeth. Participants must have some indication of gingivitis and periodontal breakdown. -
Exclusion criteria
Patients who are taking Warfarin/Coumadin Patients who are allergic to Metronidazole or chlorhexidine. Edentulous patients will be excluded by those who have at least 6 teeth can be a participant \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evidence of healing of periodontal tissues as shown by a reduction of bleeding | two weeks | Evidence of healing of periodontal tissues is assessed by measuring bleeding points and periodontal pocket depth using a dental probe. |
Countries
Canada
Outcome results
None listed