Residual Paralysis, Post-Anesthesia
Conditions
Keywords
Cost Analysis, Postoperative Complications, Length of Stay, Intensive Care Units
Brief summary
This is a secondary analysis of a previously performed prospective, observer-blinded, observational study at Massachusetts General Hospital. The primary aim of this study is to evaluate the effects of residual paralysis at admission to the post-anesthesia care unit (PACU) on total costs of hospital care. Secondary analyses will be conducted to evaluate the effects of postoperative residual paralysis on potential cost-influencing factors, i.e. incidence of minor and major postoperative respiratory complications, hospital length of stay (LOS), unplanned intensive care unit (ICU) admission rate, as well as length of stay in the PACU.
Interventions
PROCEDUREQuantitative measurement of neuromuscular transmission
Quantitative measurement of neuromuscular transmission with train-of-four watches.
Sponsors
Merck Sharp & Dohme LLC
Massachusetts General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Each subject has been given non-depolarizing neuromuscular blocking agents as part of general anesthesia. * Each subject must be at least 18 years of age * Train-of-four monitoring in the post-anesthesia care unit
Exclusion criteria
* The subject is scheduled to be transferred to an intensive care unit after surgery. * Children and pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital costs | Patients will be followed from date of admission to date of hospital discharge, an expected 2 days to 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Hospital Length of Stay | within 100 days after surgery |
Other
| Measure | Time frame | Description |
|---|---|---|
| Incidence of postoperative respiratory complications | Within one month after surgery | — |
| Incidence of unplanned postoperative intensive care unit admission | Within one week after surgery | Incidence of unplanned postoperative intensive care unit admission due to respiratory failure, pulmonary edema and arrhythmia. |
| Length of stay in the post-anesthesia care unit (PACU) | Patients will be followed until PACU discharge, an expected 2 days to 2 weeks | — |
Countries
United States
Outcome results
None listed