Effect of Thoracic Epidural Analgesia for Thoracotomy on the Occurrence of AF

Effect of Thoracic Epidural Analgesia for Thoracic Surgery on Arrhythiogenesis

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01718717

Enrollment

Registered

2012-10-31

Start date

2014-12-31

Completion date

2017-01-31

Last updated

2014-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posterolateral Thoracotomy, Lung Resection, Thoracic Epidural Analgesia, Sympathetic Outflow, Atrial Fibrillation

Keywords

Thoracotomy, Thoracic epidural analgesia, Arrythmiogenesis, Atrial fibrillation, Sympathetic outflow

Brief summary

Thoracic epidural anesthesia and analgesia for patients undergoing lung resection can reduce the occurrence of AF if it is continued for six postoperative days instead of just three.

Detailed description

THEA is considered a very effective technique of providing intra and post-operative analgesia for thoracic surgical procedure and it seems that can also be effective in reducing the incidence of postoperative AF in patients undergoing lung resection. Nevertheless the timing of stopping the epidural analgesia and its further substitution with other therapies, remains unclear. In this study patients who are scheduled for lung resection surgery will undergo the surgery under combined general anesthesia with volatile anesthetics and thoracic epidural anesthesia. Immediately after surgery the patients will be divided into two groups: * those who will receive thoracic epidural analgesia for 6 days * those who will receive thoracic epidural analgesia for 3 days and will then switch to intravenous morphine for another 3 days All the patients will be monitored daily for arrythmias

Interventions

OTHERThoracic Epidural Analgesia (TEA)

OTHERTEA followed by Intravenous morphine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* lung resection * pneumonectomy

Exclusion criteria

* Patient refusal * AF (present or in the past * contraindications for epidural catheter placement

Design outcomes

Primary

Measure	Time frame	Description
Occurrence of AF	6 postoperative days	Every day, for the first 6 postoperative days, the investigators will record an ECG of the patient, and look after for any presence of AF

Secondary

Measure	Time frame	Description
Quality of analgesia	6 postoperative days	The investigators will record the quality of analgesia, as it can be measured with VAS, for the 6 first postoperative days for all patients

Countries

Greece

Contacts

Primary ContactMetaxia Bareka, Medicine

barekametaxia@hotmail.com00306947845083

Backup ContactMarina Simaioforidou, Medicine

msimaiof@otenet.gr00306972202573

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026