Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01718405

Enrollment

150

Registered

2012-10-31

Start date

2012-11-30

Completion date

2017-11-30

Last updated

2012-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Executive Function

Brief summary

Studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise. The main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.

Interventions

OTHERCognitive function after exercise test

The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.

GENETICBlood sample analysis

In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Physical Education Students * Able to sign consent form

Exclusion criteria

* Competitive athletes * Smokers * Neurologic or psychologic orders * Chronic diseases * Head Injuries * Hospitalization in the previous 3 months * Pregnant

Design outcomes

Primary

Measure	Time frame	Description
Cognitive Functioning After Exercise	Five minutes	Computerized battery of tests evaluating cognitive functioning

Other

Measure	Time frame	Description
Genetic Variation Associated with Different Cognitive Functioning	Two years	Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.

Countries

Israel

Contacts

Primary ContactSharon Tsuk, PhD

sharontsuk1@gmail.com972-522-640642

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026