Multiple Sclerosis
Conditions
Keywords
combined training, insulin resistance
Brief summary
the purpose of this study is to investigate the development of insulin resistance in multiple sclerosis patients + explaining the effects of a combined training programme on insulin resistance, muscle power and aerobic capacity in multiple sclerosis patients
Interventions
BEHAVIORALTraining
Sponsors
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) between 0.5 and 6 * Be able to train 5 times in 2 weeks at the University
Exclusion criteria
* Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2) * Having had an relapse in a period of 3 months prior to the start of the intervention period * Having an relapse during the intervention period * Pregnancy and other contra indications for physical activity * Mental disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| insulin sensitivity (insulin profile) | change from baseline to 24 weeks | glucose and insulin concentration measurements in blood |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| aerobic capacity - lactate concentrations | change from baseline to 24 weeks | by means of a submaximal endurance test (ergometer) to determine lactate concentrations (mmol/L) |
| cytokine profile | change from baseline to 24 weeks | measurements of blood cytokine levels |
| walking performance | change from baseline to 24 weeks | Walking performance will be assessed by means of 2 and 6 minute walk test, 25-foot walk test, Chair rise test, Stair climb test |
| Self-reported measures | Change from baseline to 24 weeks | The self-reported measures contains some questionnaires |
| aerobic capacity | change from baseline to 24 weeks | by means of a submaximal endurance test (ergometer) |
| muscle strength of knee flexor | change from baseline to 24 weeks | by means of an isokinetic dynamometer the muscle strength and endurance will be measured |
| muscle strength of knee extensor | change from baseline to 24 weeks | by means of an isokinetic dynamometer the muscle strength and endurance will be measured |
| muscle strength of elbow flexor | change from baseline to 24 weeks | by means of an isokinetic dynamometer the muscle strength will be measured |
| muscle strength of elbow extensor | change from baseline to 24 weeks | by means of an isokinetic dynamometer the muscle strength will be measured |
| body composition | Change from baseline to 24 weeks | Weight, body fat% and lean tissue% will be assessed by means of a DEXA (Dual-energy X-ray absorptiometry) scan |
Countries
Belgium
Outcome results
None listed