The Effects of Puberty and Weight on Sugar Metabolism in Children

The Role of Puberty and Insulin Resistance in the Development of Hyperglucagonemia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01718080

Enrollment

Registered

2012-10-31

Start date

2012-10-31

Completion date

2015-06-30

Last updated

2017-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adolescent, Leanness, Overweight

Keywords

Obese, Lean, Pubertal, Prepubertal, Glucose, Adolescents, Type 2 Diabetes

Brief summary

Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal. * For this, we need to compare lean and overweight children. * We need to study them before and during puberty. * All children in the study will be tested before and after a liquid meal.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

8 Years to 17 Years

Healthy volunteers

Yes

Inclusion criteria

All groups: Healthy lean and otherwise healthy overweight children and adolescents between the ages of 8 and 17.

Exclusion criteria

Same for all groups The subjects will be excluded if they have: * a history of chronic disease * allergy to acetaminophen * evidence or history of chemical abuse * abnormal lab values * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Overweight and Lean Children Sugar Metabolism Before and During Puberty	4 hours	Too much weight gain can cause changes in the substances that control blood sugar and hunger in the body. Scientists need to compare these substances in lean and overweight children before and during puberty. These substances can be measured before and after a meal in the blood and in the urine. The way your stomach moves food can change your sugar levels. We want to understand how diabetes develops by studying these things. This can help find better ways to prevent and treat diabetes.

Countries

United States

Outcome results