Major Depressive Disorder
Conditions
Keywords
MDD, depression, major depressive disorder, adolescent
Brief summary
The goal of the study is to examine how cognitive behavioral therapy (CBT), a common treatment for adolescent depression, affects brain functioning. Depressed adolescents will complete an initial assessment consisting of an interview, questionnaires, computer tasks, and an EEG recording. EEG (electroencephalography) measures brain activity by recording the electrical activity along the scalp caused by the firing of neurons within the brain. They will then complete 12 sessions of cognitive behavioral therapy, which will be 50 minutes long and held once a week for 12 weeks. Before their third therapy session, participants will complete a computer task while EEG data are recorded. After completing the treatment, the participants will complete a final assessment, which will include questionnaires, computer tasks, and an EEG recording. They will also complete follow-up assessments over the phone 1, 3, and 6 months after completing the treatment. This study will also include healthy control participants. They will complete an initial assessment consisting of an interview, questionnaires, computer tasks, and an EEG recording. Three weeks later, they will return to complete a behavioral task while EEG data are recorded. Twelve weeks after the initial assessment, they will complete a final assessment, which will include questionnaires, computer tasks, and an EEG recording.
Detailed description
The purpose of the study is to examine the impact of individual cognitive behavioral therapy (CBT) for adolescent depression on neural functioning. Specifically, the study will utilize Brent and Poling's (1997) cognitive behavioral therapy (CBT) manual (Cognitive Therapy Treatment Manual for Depressed and Suicidal Youth), and investigators will examine pre- to post- neural activity patterns for children and adolescents who receive individual CBT for depression. Electroencephalography (EEG) techniques will be utilized to assess treatment-related effects on brain activity (i.e., anterior cingulate cortex and dorsolateral prefrontal cortex functioning). Neural activity patterns will also be compared to non-depressed, healthy controls.
Interventions
BEHAVIORALCognitive Behavioral Therapy
12 sessions of cognitive behavioral therapy
Sponsors
National Institute of Mental Health (NIMH)
Mclean Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
13 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
, Major Depressive Disorder Participants: * Ages 13-18 years at time of initial assessment * Female * Current major depressive disorder (MDD) diagnosed according to the K-SADS Axis I semi-structured interview * English as first language or English fluency
Exclusion criteria
, Major Depressive Disorder Participants: * Male * Mania/Hypomania * Current anxiety disorders \[e.g., Panic Disorder (PD), Generalized Anxiety Disorder (GAD), Obsessive Compulsive Disorder (OCD)\] * Eating Disorders * Substance Abuse/Dependency * Conduct Disorder/Antisocial Disorder * ADHD * Psychosis * Mental Retardation * Organic Brain Syndrome * Current Psychotherapy Treatment * Medical & neurological illness (head injury, loss of consciousness for more than 5 minutes, seizures) * Current use of psychotropic medication for treatment of MDD with the exception of SSRIs (selective serotonin reuptake inhibitors) * Active suicidality Inclusion Criteria, Healthy Control Participants: * Ages 13-18 years at time of initial assessment * Female * English as first language or English fluency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG Activity | 12 weeks | EEG and ERP measures collected during resting state and behavioral tasks |
Countries
United States
Outcome results
None listed