To Assess the Long-term Risk for Adverse Events After PE.
Conditions
Brief summary
Chronic thromboembolic pulmonary hypertension (CTPH) is associated with considerable morbidity and mortality. Its incidence after pulmonary embolism and associated risk factors are not well documented in Chinese population. We conducted a prospective, long-term, follow-up study to assess the incidence of symptomatic CTPH in consecutive patients with an acute episode of pulmonary embolism but without prior venous thromboembolism. Patients with unexplained persistent dyspnea during follow-up underwent transthoracic echocardiography and, if supportive findings were present, ventilation-perfusion lung scanning and pulmonary angiography. CTPH was considered to be present if systolic and mean pulmonary-artery pressures exceeded 40 mm Hg and 25 mm Hg, respectively; pulmonary-capillary wedge pressure was normal; and there was angiographic evidence of disease.
Interventions
None listed
Sponsors
Air Force Military Medical University, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with an episode of acute symptomatic pulmonary embolism without prior pulmonary embolism or venous thrombosis
Exclusion criteria
* Have other diseases (e.g., systemic sclerosis or severe emphysema) that could have caused nonthromboembolic pulmonary hypertension, * Have preexisting exertional dyspnea, * Geographically inaccessible for follow-up, * Decline to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cumulative incidence of symptomatic CTEPH | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Risk factors for Recurrent VTE and CTEPH | 2 years |
Countries
China
Contacts
Primary ContactShengqing Li, MD, PhD
Outcome results
None listed