Anesthesia
Conditions
Keywords
Brachial Plexus, Nerve Block, Nerve Conduction
Brief summary
The purpose of this study is to determine the conducting ability of distal extremity nerves after a supraclavicular brachial plexus nerve block (with local anesthetic) has been placed at a more proximal location in the upper extremity.
Interventions
None listed
Sponsors
Defense and Veterans Center for Integrative Pain Management
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male and female military health care beneficiaries 18 years and older, capable of providing informed consent indicating awareness of the investigational nature of the study, in keeping with institutional policy * Written informed consent must be obtained from each patient prior to entering the study * Patients must be willing to have a regional anesthetic nerve block placed prior to their scheduled procedure * Patients must be willing to have neurodiagnostic tests performed prior to placement and after placement of the regional anesthesia nerve block
Exclusion criteria
* Refusal to have a brachial plexus nerve block placed * Refusal to have serial nerve conduction studies performed * Contraindication for a regional anesthesia nerve block (allergy to local anesthetic, infection at site of injection, elevated coagulation time) * Presence of conditions affecting the hand or arm (e.g., injury, infection) that might preclude the performance of nerve conduction studies * Presence of known major abnormalities of nerve conduction, e.g., absent median sensory potential in a patient scheduled for carpal tunnel release * Presence of conditions affecting the contralateral hand or arm (e.g., injury, infection) that might preclude the performance of sensory and motor studies to test block or absence of a contralateral upper extremity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compund Muscle Action Potential (CMAP) amplitude | 1 day | measured for motor studies from baseline to peak in mV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Distal Latency | 1 day | the interval between the stimulation of a compound muscle and the observed response. Normal nerve conduction velocity is above 40 m/sec in the lower extremities and above 50 m/sec in the upper extremities, but age, muscle disease, temperature, and other factors can influence the velocity. |
| Peak Latency | 1 day | * This represents conduction along the majority of the axons * It is recorded at the peak of the waveform response |
| Onset Latency | 1 day | * This represents conduction along the fastest axons * It is recorded at the initial deflection from baseline |
Countries
United States
Outcome results
None listed