VIPER: Veterans Integrated Pain Evaluation Research

VIPER: Veterans Integrated Pain Evaluation Research- Molecular Subtypes of Chronic Pain Syndromes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01715766

Acronym

VIPER

Enrollment

124

Registered

2012-10-29

Start date

2012-01-31

Completion date

2017-02-28

Last updated

2019-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

Proteomics study, biomarker study of pain

Brief summary

The purpose of the study is to learn about the causes of different types of pain that can occur in people who have had an amputation. By gathering information through blood tests, photographs, a nerve test, and questionnaires, we hope to de-code how each individual's special characteristics affect the type and amount of pain they experience in their amputated limb.

Detailed description

Studies have already shown that pain following amputation might be caused by differences in a person's genes. This study may help us find out how genes affect the way you feel pain and why you may feel more or less or different kinds of pain than another person with a similar amputation. What we learn in this research study may lead to discoveries as to why some painkillers work better for some people than others.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Male and female active duty military personnel age 18 years and older undergoing treatment at WRAMC and future WRNMMC with the diagnosis of post injury amputation of 1 limb, more than 3 but less than 18 months prior to enrollment. In particular, phantom limb pain patients will be included

Exclusion criteria

* Severe Traumatic Brain Injury (Primary major head trauma and diagnosis of traumatic brain injury resulting in documented, permanent or prolonged cognitive deficits that would preclude participation in the study (i.e. decreased intellectual capacity, marked memory deficits, or inability to communicate verbally or in writing) * Significant cognitive deficits that would preclude participation in the study. * Substantial hearing loss without alternative means of communication. * Documented spinal cord injury with permanent or persistent deficits. * Diagnosis of fibromyalgia or other chronic pain syndrome such as chronic headaches. * Evidence of ongoing tissue damage pain, infection, bone spur, or poorly fitting prosthesis.

Design outcomes

Primary

Measure	Time frame	Description
Proteomics	1 day	To determine which proteins represent circulating qualitative and quantitative biomarkers of pain.

Countries

United States

Outcome results