Uterine Leiomyoma
Conditions
Keywords
uterine leiomyoma, laparoscopic myomectomy, intraoperative blood loss, ascorbic acid
Brief summary
The investigators want to know whether the intravenous ascorbic acid would reduce the blood loss during laparoscopic myoma surgery. The investigators randomized patients into intravenous ascorbic acid group and placebo group and examined the blood loss in both groups.
Interventions
DRUGascorbic acid
ascorbic acid 2g in normal saline 500ml IV start 30min before the operation and infusion for 2 hour
DRUGNormal saline
normal saline 500ml IV
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* uterine myoma * be planning to laparoscopic myomectomy * images ; the number of myoma \<4 * images ; the diameter of the largest myoma \<9cm
Exclusion criteria
* be planning other surgery in addition to laparoscopy * clinically significant coagulation abnormality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss | during laparoscopic myomectomy |
Other
| Measure | Time frame | Description |
|---|---|---|
| time of operation | during laparoscopic myomectomy | — |
| the amount of transfusion | during laparoscopic myomectomy | — |
| the difference of hemoglobin | postoperative day 1 | postoperative day 1 hemoglobin - preoperative hemoglobin + hemoglobin increased by transfusion (hemoglobin 1 per RBC 1 pack transfusion) |
| acute urinary retention | 2days after the operation | — |
Countries
South Korea
Outcome results
None listed