Chronic Obstructive Pulmonary Disease
Conditions
Keywords
muscle fibre, capillary, rehabilitation, exercise training
Brief summary
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.
Interventions
OTHERpulmonary rehabilitation
3-week rehabilitation including exercise training, breathing therapy, psychosocial support, medical treatment etc.
Sponsors
German Sport University, Cologne
Schön Klinik Berchtesgadener Land
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* chronic obstructive pulmonary disease * FEV1%pred. \< 50%
Exclusion criteria
* acute exacerbation * exacerbation in the last 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the amount of capillaries in muscle fibre type I | change from pre (day 1) to post rehabilitation (day 21) |
Secondary
| Measure | Time frame |
|---|---|
| Change in the amount of capillaries in muscle fibre type IIa | Change from pre (day 1) to post rehabilitation (day 21) |
| Change in the cross-sectional area of muscle fibre type I | Change from pre (day 1) to post rehabilitation (day 21) |
| Change in the cross-sectional area of muscle fibre type IIa | Change from pre (day 1) to post rehabilitation (day 21) |
Countries
Germany
Outcome results
None listed