The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Study of Pepsin Levels in the Broncho-Alveolar-Lavage Fluid of Patients With Idiopathic Pulmonary Fibrosis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01714934

Enrollment

Registered

2012-10-26

Start date

2013-01-31

Completion date

2014-12-31

Last updated

2012-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IDIOPATHIC PULMONARY FIBROSIS

Keywords

IDIOPATHIC PULMONARY FIBROSIS, MICROASPIRATION

Brief summary

The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging. Pepsin is a proteolytic enzyme present in the gastric juice. Microaspirations of gastric content were described as a potential factor for injury in many chronic lung disorders. Bronchoalveolar lavage (BAL) is a routine investigation technique in interstitial lung diseases. The presence of pepsin in the BAL fluid recovered from patients with IPF may indicate a possible role for gastric microaspirations in the pathogenesis of the disease.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* patients with interstitial lung disorders including IPF

Exclusion criteria

* patients younger than 18 years or older than 85, * pregnant women, * patients that present with medical conditions contra -indicated for performing bronchoscopy including sedation

Design outcomes

Primary

Measure	Time frame
BAL Pepsin level	18 MONTHS

Countries

Israel

Outcome results