Smoking Cessation
Conditions
Brief summary
Electronic cigarettes or e-cigarettes (EC) may have a potential public health benefit as a safer alternative to smoking and possibly also as an aid in tobacco dependence treatment. However, there are concerns about their safety and whether they can deliver nicotine consistently and in doses necessary for such effects. To be able to consider the safety of ECs and their potential in harm reduction, data are needed comparing the exposure to the potential toxicant, acrolein, in smokers of conventional cigarettes, users of EC, and people who use both products at the same time. To accurately assess EC nicotine delivery, data are needed from people who use them regularly, as there is some evidence of higher and faster nicotine absorption in experienced users compared with naïve users who try them once in an artificial laboratory setting. This study will provide information on both of these issues. Forty smokers will be given EC to use, in addition to behavioural support, as part of a stop smoking attempt. Levels of acrolein and nicotine will be measured before and after 4 weeks of EC use.
Interventions
OTHERe-Cigarette
Sponsors
Queen Mary University of London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Smokers who want help in quitting * Aged 18 or over
Exclusion criteria
* Women who are pregnant or breastfeeding * People with any current serious illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in urinary 3HPMA levels after 4 weeks use of electronic cigarettes. | 4 weeks | Change in urinary 3HPMA levels (a metabolite of acrolein) after 4 weeks use of electronic cigarettes, in both individuals who have stopped smoking conventional cigarettes and those who are still using them. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in nicotine levels after 4 weeks use of electronic cigarettes (EC) | 4 weeks | Change in blood nicotine levels obtained from using an EC after 4 weeks use of electronic cigarettes (10 participants only). |
| Electronic cigarette acceptability | 6 months | Participants' views on electronic cigarettes |
| Use of electronic cigarettes | 6 months | Participants' use of electronic cigarettes |
Countries
United Kingdom
Outcome results
None listed