Nitrate and Exercise-induced Cardiac Troponin T in Type 2 Diabetes

The Impact of Dietary Nitrate Supplementation on Exercise-induced Cardiac Troponin T Release in Type 2 Diabetic Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01714674

Acronym

NO troponin

Enrollment

Registered

2012-10-26

Start date

2012-10-31

Completion date

2013-05-31

Last updated

2012-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Keywords

cardiac troponin T, cTnT, exercise, dietary nitrate

Brief summary

Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours following a single bout of moderate-intensity endurance-type exercise. This phenomenon is likely attributed to cardiac ischemia-reperfusion injury caused by reduced nitric oxide (NO) bioavailability. Recent evidence indicates that ingestion of dietary nitrates dramatically increases the bioavailability of NO, and as such, may be protective against cardiac ischemia-reperfusion injury. The investigators hypothesize that dietary nitrate supplementation blunts the rise in cTnT levels following exercise in type 2 diabetic patients.

Interventions

DIETARY_SUPPLEMENTDietary nitrate beverage

ingestion of single dose NaNO3 beverage two hours prior to exercise bout

DIETARY_SUPPLEMENTNaCl beverage

ingestion of single dose NaCl beverage two hours prior to exercise bout

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

* exercise-induced cTnT release (\>3ng/L)

Exclusion criteria

* HbA1c \<6.0% or \>10.0% * morbid obesity (BMI\>35 kg/m2) * incident cardiovascular events in the last year (heart attack, stroke * use medication which contain nitrates and/or having vasodilatory effects

Design outcomes

Primary

Measure	Time frame	Description
Cardiac troponin T	9 hours, hourly time intervals	Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise.

Secondary

Measure	Time frame	Description
Plasma nitrate	9 hours, hourly time intervals	Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise.
Plasma nitrite	9 hours, hourly time intervals	Plasma nitrite levels will be assessed before exercise and over the 6-hour period following a single session of exercise.
Blood pressure	day	Blood pressure will be measured various time during the day.

Countries

Netherlands

Contacts

Primary ContactJan-Willem van Dijk, MSc

janwillem.vandijk@maastrichtuniversity.nl+31(0)433881394

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026