Autonomic Nervous System Activity and Oculocardiac Reflex.

Prediction of Oculocardiac Reflex in Relationship to Autonomic Nervous System Activity, Mesured With the Use of ECG HRV Analysis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01714362

Enrollment

Registered

2012-10-25

Start date

2009-10-31

Completion date

2018-10-31

Last updated

2022-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bradycardia During Pulling of Eyeball

Keywords

oculocardiac effect, bradycardia, HRV

Brief summary

Pulling the eyeball during ophthalmic surgery provokes decrease in heart rate. This phenomenon is called oculocardiac reflex. In some patients asystole may occur. Other cardiac features of this reflex include hypotension, dysrhythmias, atrioventricular block. These cardiovascular disturbances may lead to decreased perfusion and ischemia of vital organs. Patients with existing cardiovascular disease are in risk of complications. Cardiovascular system is mainly innervated with autonomic nervous system (ANS). Sympathetic/parasympathetic activity may be determined by Heart Rate Variability (HRV). HRV analysis based on short 5 minutes electrocardiography has been found useful for prediction of hypotension and bradycardia during induction of general anaesthesia and during spinal block. The aim of this study is to verify whether it is possible to predict oculocardiac reflex with the use of HRV analysis for ANS activity assessment, measured prior to the ophthalmic surgery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* planned surgery * over 18 years of age * surgery under general anaesthesia

Exclusion criteria

* urgent surgery * under 18 years of age and over 65 * patients with generalised, nontreated disease * patients receiving beta blockers or calcium channel blocker * diabetic patients * patients operated under peri or retrobulbar anaesthesia

Design outcomes

Primary

Measure	Time frame
oculocardiac reflex occurence in relation to autonomic system activity	perioperatively - about 2 hours

Countries

Poland

Outcome results