Endothelial Function
Conditions
Keywords
endothelial function, sympathetic nervous system
Brief summary
The purpose of this study is to determine whether interventions aimed at increasing sympathetic tone modify endothelial function measures as assessed by the measurement of flow-mediated dilation (FMD) and constriction (FMC). The investigators hypothesize that the three interventions under study will increase FMC while causing a blunting in FMD. Further, the investigators plan to study the circadian variability of FMC and FMD. The investigators hypothesize a peak of FMD in the late hours of the day and a peak of FMC in the early hours.
Interventions
PROCEDUREMental stress
Subjects will be asked to perform complex mathematic operations at a very fast pace
OTHERno intervention
control visit
PROCEDUREMyogenic activation
A pneumatic cuff will be inflated to suprasystolic pressure around both thighs and the subjects will be asked to perform plantar flexion exercises.
PROCEDURECold pressure test
A hand will be placed in ice-cold water.
Sponsors
Johannes Gutenberg University Mainz
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers with no cardiovascular risk factor, no current disease, normal laboratory parameters and ECG.
Exclusion criteria
* any active disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in FMD in response to sympathetic activation | Change in FMD before versus 1 Minute after begin of intervention | Flow-mediated dilation will be measured at rest and during each of the interventions. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in FMC during sympathetic activation | Change in FMC before versus 1 minute after begin of each intervention | Change in Flow-mediated constriction induced by each of the interventions. |
Countries
Germany
Outcome results
None listed