Cervical Spinal Cord Injury
Conditions
Keywords
trauma, spinal cord injury, cervical spine
Brief summary
Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.
Detailed description
Diffusion tensor imaging (DTI) parameters will correlate with severity of spinal cord injury in SCI patients as seen in rodent models. We will test whether the quantitative decrease in axial (λ║) diffusivity (a biomarker of axonal injury), will predict long-term functional outcomes for patients with a SCI. Specific Aim: To examine patients after an acute SCI using DTI and to correlate the extent of acute decrease in λ║ with the presenting ASIA motor score and long-term functional outcome of the patient.
Interventions
None listed
Sponsors
Washington University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* 18-65 years of age * Cervical spinal cord injury * physically and mentally willing to comply with imaging * lives in immediate area with no plans to relocate
Exclusion criteria
* Associated moderate to severe head injury * Active malignancy * Previous spinal cord injury * pregnancy * inability to tolerate MRI scanning
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in AISA score | 24 months | Patients will be followed for the duration of their hospital stay with clinical follow-up out to 2 years. ASIA scores will be correlated with admission DTI findings(Axial Diffusivity). |
Countries
United States
Outcome results
None listed