Warts
Conditions
Keywords
Warts, salicylic acid, ethyl pyruvate
Brief summary
Plantar warts on the sole of the foot are among the most common warts seen in podiatry clinics. Some patients are readily cured by simple standard of care treatments that include wart debridement (trimming or excision) and application of 17% salicylate (commercially known as Compound W)or by other treatments that may be painful and affect mobility. No treatment is consistently effective and most patients fail treatment multiple times. Ethyl pyruvate (EP)is a common food additive noted to be 'generally regarded as safe' that may improve the activity of salicylate in wart treatment by improving the ability to penetrate and/or persist in the skin. The use of 17% salicylate with the addition of EP may improve cures of common foot plantar warts in subjects who also be receiving other standard-of-care treatment.
Interventions
DRUG17% Salicylate with ethyl pyruvate
DRUGSalicylates
Sponsors
Main Line Health
Grossman, Michael, D.P.M.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
12 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* evidence of skin plantar wart(s)
Exclusion criteria
* iodine allergy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To determine if salicylate with ethyl pyruvate (SA-EP) eliminates plantar warts more quickly than salicylate (SA) alone. | 16 weeks | Subjects' wart(s) are treated with SA or SA-EP every two weeks for up to 16 weeks. |
Secondary
| Measure | Time frame |
|---|---|
| To determine if salicylate with ethyl pyruvate (SA-EP) in treatment of plantar warts causes adverse events other than those known to occur with SA (salicylate)alone. | 16 weeks |
Countries
United States
Contacts
Primary ContactMichael Grossman, DPM
Outcome results
None listed