The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01711996

Enrollment

Registered

2012-10-23

Start date

2012-08-31

Completion date

2013-08-31

Last updated

2021-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ureteropelvic Junction Obstruction

Keywords

hydronephrosis, biopsy, biomarker

Brief summary

Urinary Neutrophil gelatinase associated lipocalin (NGAL) has been recently reported to be related with the degree of hydronephrosis in pediatric ureteropelvic junction obstruction (UPJO) patients. We are trying to analyze whether it is related with the grade of renal injury in UPJO patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 3 Years

Healthy volunteers

Yes

Inclusion criteria

\<Group 1\> 1. 0-3 year old patients with SFU grade 2 or more hydronephrosis without ureteral dilatation 2. needs pyeloplasty due to differential renal function (DRF)\<40%, decreased DRF by more than 5%, development of urinary tract infection, development of urinary stone, and development of pain related with UPJO \<Group 2\> 1\. 0-3 year old patients with SFU grade 3 or 4 hydronephrosis without ureteral dilatation 2. doesn't meet the above criteria for the indication of pyeloplasty \<Group 3\> 1\. 0-3 year old children without any abnormality of urinary tract

Exclusion criteria

\<Group 1\> 1. patients with contralateral disease affecting DRF 2. history of previous urinary tract surgery 3. follow up loss before diuretic renogram performed at 6-12 months from operation \<Group 2, 3\> 1\. patients with contralateral disease affecting DRF 2. history of previous urinary tract surgery

Design outcomes

Primary

Measure	Time frame	Description
The level of urinary NGAL and the degree of renal injury	6 month after operation	Analysis of correlation between the level of urinary NGAL and the degree of renal injury

Countries

South Korea

Outcome results