The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01711957

Enrollment

250

Registered

2012-10-23

Start date

2008-01-31

Completion date

2013-01-31

Last updated

2012-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complication, Death

Keywords

Complications, Mortality, Liver transplantation, Platelet count, Survival

Brief summary

Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients, was shown to be associated with postoperative morbidity and mortality after partial hepatectomy. The investigators aim at evaluating whether postoperative low platelet counts are indicators of short- and long-term outcomes after liver transplantation.

Interventions

PROCEDURELiver transplantation

Standardized technique of liver transplantation Organ procurement follow the rules of the Swiss transplant society

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>18 years old * End stage liver disease * Cadaveric-donor liver transplantation

Exclusion criteria

* Age \<18 years old * Pregnancy * Living-related liver transplantation

Design outcomes

Primary

Measure	Time frame	Description
Severe complication after liver transplantation	90 days	The severity of complications will be graded according to the Clavien-Dindo classification by outcome. Grade III to V complications will be considered as severe.

Secondary

Measure	Time frame	Description
Primary graft non-function	first postoperative week	Defined as death or retransplantation within the first postoperative week after exclusion of technical, immunological, and infectious causes
Delayed graft function	7 days after liver transplantation	Defined as the presence of at least one of the following parameter at 7 days after LT: serum bilirubin \> 10 mg/dL and International Normalized Ratio (INR) \>1.6 or Alanine aminotransferase serum level (ALT) \>2000UI/L

Other

Measure	Time frame
Patient survival	3-year

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026