Healthy
Conditions
Keywords
nitric oxide, cycling performance, lactate, VO2
Brief summary
Acute supplementation of Neo40(TM), a nitrate lozenge, will improve cycling performance
Interventions
DIETARY_SUPPLEMENTPlacebo
Same form factor and flavor as test lozenge but contains no active ingredients
DIETARY_SUPPLEMENTNitrate supplement with caffeine
Lozenge consisting of beetroot and 75 mg caffeine
Sponsors
Neogenis Laboratories
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Regular commuter cyclist or spin class participant * Male (VO2max \< 50) or Female (VO2max \< 45) * Healthy * Blood pressure below 140/90 * Non-smoker
Exclusion criteria
* Does not cycle 2-3 times/week * Regular consumption of performance-enhancing substances * Type I or Type II diabetes * Renal, hepatic or cardiac disease * Current infectious disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improved Time Trial Performance | After 20 min steady-state cycling | Participants will cycle 20 min at increasing intensity: 8 min at 55% VO2max, 6 min at 65% VO2max, 6 min at 75% VO2max. The 20 km time trial consists of rolling hills. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improved work efficiency | During 20 min steady-state cycling | Expired gases will be collected and compared to expected VO2. Blood will be collected prior to treatment, prior to exercise and during each cycling intensity to analyze lactate accumulation. |
Countries
United States
Outcome results
None listed