Lactate Clearance According to the Presence of Hepatic Dysfunction

Lactate Clearance and Mortality in Patients With Severe Sepsis and Septic Shock: Comparison by Hepatic Dysfunction

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01709565

Enrollment

245

Registered

2012-10-18

Start date

2012-07-31

Completion date

2014-06-30

Last updated

2012-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Failure, Sepsis

Keywords

Sepsis, Lactic acid, Shock, Resuscitation

Brief summary

The purpose of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction.

Detailed description

Lactate clearance is well known to be associated with mortality in patients with severe sepsis and septic shock. To normalize lactate levels is one of important goals of early resuscitation of sepsis patients. Lactate clearance can be changed by various factors including patient characteristics, severity of shock, and treatment. In particular, hepatic dysfunction might impair the clearance of lactate because liver is a principal organ for lactate metabolism. However, an association between lactate clearance and hepatic failure has not been evaluated during initial resuscitation of patients with severe sepsis and septic shock. The primary goal of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction. The secondary goal is to evaluate if lactate clearance is associated with mortality even in patients with hepatic dysfunction.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who presented with septic shock or severe sepsis within 6 hours after emergency department arrival

Exclusion criteria

* Terminal malignancy or illness with a expected survival \< 4 months * Patients who previously signed Do Not Resuscitate or Do Not Intubate orders * Patients who do not undergo the early goal-directed therapy

Design outcomes

Primary

Measure	Time frame	Description
Lactate clearance	at 6-hour from the time of enrollment	\[(initial lactate - delayed lactate)/ initial lactate\] \*100%

Secondary

Measure	Time frame
In-hospital mortality	within the first 28-day after emergency department arrival

Countries

South Korea

Contacts

Primary ContactIk Joon Jo, PhD

drjij@skku.edu+82-2-3410-2053

Outcome results